GuideSkill: Evolving Executable LLM Agent Skills for Guideline-Grounded Clinical Reasoning

Abstract

arXiv:2607.26160v1 Announce Type: new Abstract: Clinical practice guidelines (CPGs) encode diagnostic criteria, but LLM systems typically retrieve guideline text or absorb it through training rather than execute its rules. We introduce GuideSkill, an external reasoning layer that compiles disease-specific criteria into executable functions returning ordinal diagnostic-support scores. GuideSkill-Zero is initialized from guidelines, while GuideSkill-Evo uses case--diagnosis pairs to refine covered